Oxygen Uptake Kinetics in Type 1 Diabetes
Research type
Research Study
Full title
Pulmonary Oxygen Uptake and Muscle Deoxygenation Kinetics in Patients with Type 1 Diabetes
IRAS ID
220064
Contact name
Richie Philip Goulding
Contact email
Sponsor organisation
Liverpool Hope University
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
This study will attempt to assess whether the oxygen uptake response at the onset of exercise in type 1 diabetic individuals is slowed when compared to normal, healthy individuals. It is known that individuals with type 1 diabetes of demonstrate impaired exercise capacity, however whether this reduced exercise capacity is due to slower oxygen uptake is not known. This study will therefore assess maximum exercise capacity and oxygen uptake responses to moderate exercise in patients with type 1 diabetes and a group of healthy individuals without diabetes. This study will therefore provide insight into the mechanisms behind exercise intolerance in type 1 diabetes.
Individuals with type 1 diabetes between the ages of 18-40 years without any significant complications and with a disease duration of 2-20 years will be eligible for the study. A group of healthy control participants between the ages of 18-40 years without any significant health complications will also be recruited.
The study will be conducted in the Sports Performance laboratories at Liverpool Hope University. The study will last for 2-4 weeks for each participant, and will involve 2 separate visits to the laboratory. The first visit will assess the maximum exercise capacity of each participant. This visit will involve a maximal exercise test to determine the maximum amount of oxygen each participant can utilise during high-intensity exercise. The second visit will involve 4 sets of separate 6-minute moderate-intensity exercise bouts, each separated by 10 minutes of rest. All tests will be performed on a type of stationary bicycle known as an ergometer.
The results of this study should therefore provide important information regarding the causes of exercise intolerance in type 1 diabetes.REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
17/SW/0116
Date of REC Opinion
22 Jun 2017
REC opinion
Further Information Favourable Opinion