Oxidative Stress Response in Patients with Severe Aortic Stenosis
Research type
Research Study
Full title
Oxidative Stress in Patients with Severe Aortic Stenosis Undergoing Transcatheter or Surgical Aortic Valve Replacement
IRAS ID
206946
Contact name
Michael Mahmoudi
Contact email
Sponsor organisation
University Hospital Southampton NHS FT
Duration of Study in the UK
0 years, 5 months, 0 days
Research summary
Severe restriction in the mobility of the aortic valve, a condition called severe aortic stenosis, is treated either by open heart surgery also referred to as surgical aortic valve replacement (SAVR) or through a less invasive procedure called transcatheter aortic valve replacement (TAVR) where a new valve is implanted within the pre-existing valve through the groin artery.
Both procedures have been reported to lead to the production of molecules called reactive oxygen species (ROS) which can damage the heart muscle and cause adverse clinical outcomes. Because SAVR requires the use of a bypass machine and is a much longer procedure than TAVR, it has been suggested that ROS production and therefore ROS mediated heart muscle damage may be greater in patients undergoing SAVR. This has never been formally studied. The aim of this research is therefor to compare the amount of ROS generated during SAVR and TAVR and determine whether differences in ROS generation are related to clinical outcomes over a follow-up period of 3 months.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
16/NW/0516
Date of REC Opinion
7 Jul 2016
REC opinion
Further Information Favourable Opinion