Oxford Transplant Biobank v3

• Research type

  Research Tissue Bank

• IRAS ID

  345652

• Research summary

  Oxford Transplant Biobank

• REC name

  South Central - Oxford C Research Ethics Committee

• REC reference

  25/SC/0002

• Date of REC Opinion

  13 Feb 2025

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  Blood, urine and tissue samples will be collected from living organ donors or transplant recipients (who receive organs from living organ donors or deceased organ donors) at the Oxford Transplant Centre.

  Tissue samples that will be collected will depend upon the transplant, but may include: kidney, arterial segments, spleen, pancreas, ureter, skin, uterus or composite tissue. Samples will be collected during the transplant operation. A further kidney biopsy may be taken at a single timepoint post-transplant.

  Blood and urine samples will be collected during the donation and transplantation procedures. Further blood and urine samples are taken post-transplant as an in-patient, then at outpatient follow-up visits. A further blood and urine sample will be collected when a post-transplant biopsy is taken.

  Consent will be sought at the time of consenting for transplantation or on the day of the transplant procedure, as well as on the day of follow-up visits, and on the day of the post-transplant biopsy procedure.
  
  Blood and tissue samples will be collected from Oxford Transplant Centre patients undergiong dialysis access surgery within the Oxford Transplant Centre catchment area. Tissue samples consist of the AV fistula removed during surgery, which would normally be discarded. Consent is obtained on the day of the procedure.

  Additional blood and tissue samples will be collected from uterus transplant recipients during their pregnancy (blood and uterus biopsies), upon delivery of the baby (placenta, umbilical cord and cord blood) and at hysterectomy (uterus biopsies). Consent will be obtained at a post-transplant clinic appointment.

  All samples will be stored at the University of Oxford at the John Radcliffe and Churchill Hospitals.

• Research programme

  This research will support the Oxford Transplant Centre, part of the Nuffield Department of Surgical Sciences, University of Oxford, research community which includes researchers and their collaborators exploring the following research areas: (1) Organ Donation and Donor Management (2) Organ Preservation (3) Ischemia Reperfusion injury (4) Immunosupression and tolerance (5) Operative surgical techniques (6) Organ recipient management, including post transplant complication management (7) Management of patients on dialysis

• Storage license

  12217

• RTBTitle

  Oxford Transplant Biobank

• Establishment organisation

  Nuffield Department of Surgical Sciences, University of Oxford

• Establishment organisation address

  Level 6, John Radcliffe Hospital

  Oxford

  OX3 9DU