Oxford Musculoskeletal Biobank

• Research type

  Research Tissue Bank

• IRAS ID

  259462

• Research summary

  Oxford Musculoskeletal Biobank

• REC name

  South Central - Oxford C Research Ethics Committee

• REC reference

  19/SC/0134

• Date of REC Opinion

  14 May 2019

• REC opinion

  Favourable Opinion

• Data collection arrangements

  The Oxford Musculoskeletal Biobank (OMB) is a resource of blood, tissue and prosthetic implant samples that have been donated by patients for use in medical research (primarily Musculoskeletal). The biobank provides a simple and efficient way to collect and store samples, historic data, and follow-up data according to regulatory requirements.

  OMB broadly aims to:
  -coordinate the collection and storage of human samples for musculoskeletal research.
  -act as a 'safe haven' for the collection and storage of human samples and data.
  -act as an 'honest broker' for the fair distribution of samples and data.
  -facilitate and streamline access to high quality samples in accordance with ethical and regulatory requirements.
  -help establish research biobanking as a routine part of healthcare provision.
  -contribute towards increased knowledge and understanding of disease in order to improve patient diagnosis, treatment and outcome.

• Research programme

  The samples and data may be used in research to understand the causes of disease with an view to improving understanding, diagnosis and treatment of disease. This may include: -investigating the causes of disease, damage and degeneration in musculoskeletal cells and tissues. -developing assays to determine the roles of growth factors,hypoxia,angiogenisis, matrix attachment and cytokine pathways in musculoskeletal disease and repair. -Establishing novel cell culture methods. -Establishing methods to discriminate structure-function relationships based on mechanical testing and biochemical composition. -Investigating evidence/ mechanisms of age-and disease-relevant epigenetic modifications in musculoskeletal tissue. -Analysing tissue for disease causing somatic mutations. -Developing novel diagnostic tools. -Investigating molecular mechanisms of disease pathogenesis.

• Storage license

  12217

• RTBTitle

  Oxford Musculoskeletal Biobank

• Establishment organisation

  Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford

• Establishment organisation address

  NDORMS

  Botnar Research Centre

  Windmill Road , Oxford

  OX3 7LD