The neuroendocrine, metabolic and autonomic response to overeating.
I S Farooqi
Cambridge University Hospitals NHS Trust and University of Cambridge
Duration of Study in the UK
3 years, 0 months, 0 days
Obesity is associated with multiple complications including high blood pressure, type 2 diabetes and hormonal problems such as infertility. The exact mechanisms by which these changes occur as people gain weight are not known.
As people eat more calories than they need (positive energy balance), there are a series of physiological changes that occur in the metabolic, neuroendocrine and autonomic systems.
We hypothesise that these changes occur even before people gain weight.
The aim of our study is to test this hypothesis by studying the response to overeating before weight gain occurs.
This study will provide a unique opportunity to identify and characterise the physiological mechanisms and changes that occur in normal weight individuals during a period of short term overeating.
The findings from this study will be relevant to understanding why and how weight gain is associated with clinical problems such as type 2 diabetes, high blood pressure, sleep problems and infertility.
East of England - Cambridge South Research Ethics Committee
Date of REC Opinion
8 Jun 2015
Further Information Favourable Opinion