OV-MRI - Version 1.0
Research type
Research Study
Full title
Oxygen ventilation MRI and cardiopulmonary limitations in obstructive airway disease
IRAS ID
308140
Contact name
Alexander Horsley
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Chronic obstructive pulmonary disease (COPD) is considered the third leading cause of death all-over the world. COPD is a chronic progressive inflammatory disease that primarily affects the airways and the lungs. The resultant airway obstruction will lead to impairment in inhaled gas distribution within the lungs, an important functional property of the lungs. Interestingly, even in patients with mild disease, this will cause the air to be trapped inside the lungs at the end of expiration causing significant breathlessness. Physiological tests have been used over years to assess for the degree of impairment in gas distribution. However, with the recent advances in imaging techniques namely the magnetic resonance imaging (MRI), novel ventilation-MRI methodology can be helpful in providing detailed and more accurate assessment of ventilation distribution.
The current study aims to assess the ability to obtain informative and repeatable MR-ventilation imaging using oxygen inhalation alone in patients with variable severity of COPD as well as in healthy volunteers. We also aim to examine how these novel measurements will relate to conventional physiological tests. We will include up to 20 patients (male or female with >30years of age) who had a diagnosis with COPD and up to 20 healthy volunteers. Participants will have several lung functions tests and one-to-two MR scan(s) while breathing oxygen over 2-3 visits for patients with COPD and 1-2 visits for healthy volunteers. Duration of study visits will vary between 2-4 hours and the whole study duration will be between 7-28 days per participant depending on subject cohort. All study tests and procedures will be conducted at Wythenshawe hospital (at the clinical research facility and cardiac MR centres).REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
22/NW/0114
Date of REC Opinion
4 May 2022
REC opinion
Further Information Favourable Opinion