Outpatient PADL clinic outcomes
Research type
Research Study
Full title
Outpatient penicillin allergy de-label clinic outcomes
IRAS ID
370900
Contact name
Neil Powell
Contact email
Sponsor organisation
Royal Cornwall Hospital NHS Trust
Duration of Study in the UK
4 years, 11 months, 29 days
Research summary
The study aim is to determine where the outpatient penicillin allergy de-label clinic influences future antibiotic prescribing. Penicillin allergy de-labelling is a term used to describe a process where a HealthCare worker asks the patient what happened when they last received a penicillin antibiotics. From that history, the healthcare worker can decide what the future likelihood is of a patient experiencing similar or worse symptoms in the future. Patients deemed unlikely to experience allergic symptoms if they take a penicillin again are offered a penicillin antibiotic to demonstrate tolerance. Once tolerance has been demonstrated then the penicillin allergy record can be removed ('de-labelled') and patients can receive penicillin antibiotics in the future. This study will collect prospective data on patients referred to the outpatient penicillin allergy de-label clinic. Patient demographics, penicillin allergy risk category, testing method and test outcome will be collected in the clinic. Data from hospital and GP records will be linked at 12 and 24 months post penicillin allergy testing to determine the number of patients who attended clinic later received antibiotics and for which indication and the name of the antibiotic.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
26/SC/0207
Date of REC Opinion
18 Jun 2026
REC opinion
Further Information Favourable Opinion