Outcomes following endoscopic resection of complex colorectal lesions
Research type
Research Study
Full title
Outcomes and risk factors for recurrence following endoscopic resection of large complex colorectal neoplasms in a UK tertiary referral centre.
IRAS ID
218592
Contact name
Andrew Emmanuel
Contact email
Sponsor organisation
King's College Hospital
Duration of Study in the UK
0 years, 9 months, 5 days
Research summary
We aim to determine the clinical outcomes and risk factors for recurrence following endoscopic resection (removal using special techniques through a flexible telescope) of large and complex polyps from the large bowel and rectum. We will also determine the outcomes following endoscopic resection of particularly complex polyps, such as those that have been subjected to previous intervention or failed attempts at resection, and investigate whether there are any characteristics of these polyps which will help predict successful resection or the likelihood of having a\n“high-risk” lesion containing cancer or pre-cancer. The study will be a retrospective review of patients’ clinical records using a clinical database maintained for patients undergoing these procedures.\n\nIn the past, patients with these large, complex polyps in the large bowel and rectum would need major surgery to remove a section of bowel. However, modern techniques, mostly pioneered in Japan and the far east, enable such tumours to be removed with special techniques using a flexible telescope (colonoscopy) without the need for surgery. These techniques are increasingly used in the west. Our institution incorporates many of the techniques preferred in both the east and west to adopt a treatment approach specific to the individual patient and the tumour characteristics. However, there is limited data about the outcomes of these techniques in western practice, although they have the potential to save many patients from the risk of undergoing major surgery which is associated with significant complications, mortality and long term functional problems. It is therefore important to determine the safety and efficacy of this less invasive organ conserving treatment using the flexible telescope in a UK setting. It would also be useful to determine the risk factors for recurrence or predictors of successful resection to help improve the selection of patients who should have the procedure and improve their outcome.\n
REC name
London - Hampstead Research Ethics Committee
REC reference
16/LO/2269
Date of REC Opinion
3 Jan 2017
REC opinion
Favourable Opinion