OUH SIRT Dosimetry
Research type
Research Study
Full title
Determination of the required radiation dose to achieve a clinically significant tumour response in patients undergoing Selective Internal Radiation therapy (SIRT), through development of clinical workflows utilizing new software for dose estimation.
IRAS ID
254517
Contact name
Rebecca Muirhead
Contact email
Sponsor organisation
Oxford University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 6 months, 30 days
Research summary
The project proposed will investigate the absorbed radiation dose to patients from SIRT therapy using new software and reconstruction methods. These will be worked into an optimised clinical workflow for use in a busy clinical department. Using doses calculated by these new methods, the project will aim to determine if there is a dose-response effect in this patient group and will aim to confirm or improve existing data that exists in the literature for this. As a secondary aim of the project, previous work will be expanded to investigate the effect on clinical response in patients with KRAS mutations as literature has conflicting reports on the difference with regards to disease progression and survival. If enough patients are available, the dose required for tumour response will be evaluated to determine if patients with KRAS mutation require a higher dose than those with a KRAS wildtype presentation.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
20/EM/0168
Date of REC Opinion
10 Jul 2020
REC opinion
Favourable Opinion