OsBONE
Research type
Research Study
Full title
Real-World Long-Term Musculoskeletal and Extra-Skeletal Outcomes of Obesity, Diabetes, Ageing, Frailty, and Sarcopenia: The Oswestry Metabolic BONE Cohort
IRAS ID
347534
Contact name
Claire Mennan
Contact email
Sponsor organisation
The Robert Jones & Agnes Hunt Orhopeadic Hospital
Duration of Study in the UK
10 years, 0 months, 0 days
Research summary
The overarching aim of this study is to look at the longitudinal skeletal and extra-skeletal health outcomes for patients at risk for fracture who are attending the RJAH metabolic bone service as standard of care. This work is designed to use data collected as standard of care as well as research specific data in consenting patients. Data from research questionnaires, biological samples, and diagnostic imaging will be analysed to provide a holistic approach to understanding why patients fracture, how best to predict future fracture risk and identify parameters of treatment response. This research will assess the well-established traditional risk factors for fracture and explore novel risk factors related to chronic conditions such as diabetes, obesity, sarcopenia, and frailty as well as novel biomarkers including metabolomics, proteomics among others, in an effort to reveal new pathological and mechanistic metabolic pathways.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
25/SC/0120
Date of REC Opinion
9 May 2025
REC opinion
Further Information Favourable Opinion