Orthopaedic Retrievals, Version 1
Research type
Research Study
Full title
Study of Retrieved Orthopaedic Implants and Associated Tissues and Data
IRAS ID
233494
Contact name
Sophie Wiliams
Contact email
Duration of Study in the UK
3 years, 4 months, 31 days
Research summary
Total joint replacement surgery is a successful operation that is used to help alleviate pain and the improve mobility of patients suffering from diseases such as osteoarthritis. However, despite the overall success of this procedure some patients will subsequently require revision surgery, where some or all of the components of the artificial joint needs to be removed and replaced. Revision surgery is a more complex procedure than primary joint replacement surgery and it is sometime considered to give less favourable functional outcome and patient satisfaction, highlighting the need for continued research to increase the longevity of artificial joints.
In order to do this research, surface characteristics such as wear and/or corrosion patterns, will be examined on orthopaedic implant components (e.g. joint replacements), that have been removed (explanted) from patients undergoing revision surgery. In some cases, the material properties of the explanted components (also called retrievals) will be examined, and wear particle analysis of tissue samples taken from around the joint at the time of revision surgery will be conducted. Other patient and surgeon related factors will also be investigated using additional information that may be collected such as gait, medical imaging (x-rays), and photographic data. Participants will be recruited from hospitals in England and Northern Ireland, and the majority of the analyses will be conducted at the University of Leeds.This study will contribute to ongoing research to help gain a better understanding of joint replacement performance whilst implanted in the body, and the results can also be used to inform the development of advanced laboratory testing that can produce wear and/or damage patterns on new artificial joints in the laboratory that replicate the wear/damage patterns observed on retrievals.
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
18/NW/0707
Date of REC Opinion
19 Oct 2018
REC opinion
Favourable Opinion