ORL-EXG-1917
Research type
Research Study
Full title
A cosmetic study to assess the efficacy of a toothpaste containing 2% Zinc Citrate Trihydrate/0.32% NaF on oral health and gingival crevicular fluid biomarkers compared to a silica toothpaste with 0.32% NaF and a 2% Zinc/ 0.3% Triclosan toothpaste.
IRAS ID
193818
Contact name
Iain Chapple
Contact email
Sponsor organisation
Unilever Research & Development
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
Gingivitis is a type of mild gum disease caused by a build-up of plaque, and which is reversible when plaque is removed. This can be shown in an experiment by not brushing an area of the mouth and allowing plaque to build up, triggering early gingivitis in the non-brushed area. When the area is later brushed using suitable toothpaste, the gum disease disappears. This experiment was initially done when diets, behaviours, and attitudes were different and there is now some doubt over whether this experiment still works. In this study we want to test that this experiment still works as if we can show that it does, it is a very useful method to help evaluate new toothpaste formulations.
This study is a randomised trial which means participants are randomly assigned one of three toothpastes to test. In addition to testing the validity of the experimental model, another objective from this study is to confirm whether we can use one of the toothpastes as a control in future studies.
REC name
West Midlands - Edgbaston Research Ethics Committee
REC reference
15/WM/0407
Date of REC Opinion
4 Dec 2015
REC opinion
Further Information Favourable Opinion