Organoids for Investigation of Therapeutic Safety and Efficacy

• Research type

  Research Tissue Bank

• IRAS ID

  362181

• Research summary

  Avatrial Therapeutic Safety and Efficacy Tissue Bank

• REC name

  Yorkshire & The Humber - Sheffield Research Ethics Committee

• REC reference

  25/YH/0216

• Date of REC Opinion

  28 Nov 2025

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  Samples are collected and anonymised from donors who are consented for research in hospitals and regulated tissue banks, both in the UK and abroad, along with some clinical/ lifestyle data. The majority of samples received in Avatrial are analysed, and a comprehensive dataset is produced which details the molecular components of the sample. This data is highly sort after by researchers. In addition some samples particularily tumour samples are used to grow 3D cell structures call Organoids. These Organoid cultures mimic the cells from which they are derived, and as such enable researchers to investigate the causes and effectiveness of treatments for diseases such as cancer

• Research programme

  Academic and commercial researchers across the world will benefit from the multiomnic datasets and organoids provided by Avatrial. The following are just some of the fields of research that will be supported by Avatrial: 1.Cancer 2.Autoimmune conditions 3 Inflammatory bowel disease (e.g., ulcerative colitis) 4.Metabolic diseases (e.g., diabetes) 5 Cardiovascular disease (e.g., ischaemic heart disease). Avatrial also mandates to give some of its profits to hospital partners and charities alike

• Storage license

  12788

• RTBTitle

  Avatrial Therapeutic Safety and Efficacy Tissue Bank

• Establishment organisation

  Avatrial Ltd

• Establishment organisation address

  Jeffrey Cheah Biomedical Centre

  Puddicombe Way

  Cambridge Biomedical Campus

  CB2 0AW