ORDIT v0.1
Research type
Research Study
Full title
Organ Dysfunction in Trauma: a national one month point prevalence study
Contact name
Karim Brohi
Contact email
Sponsor organisation
Barts Health NHS Trust
Duration of Study in the UK
1 years, 4 months, 30 days
Research summary
Traumatic injury is a leading cause of death. Severely injured patients who survive their initial injuries and are usually admitted to the intensive care unit (known as critical care). Here a proportion of patients will develop a dysfunction of vital organs (the heart, lungs, liver for example) known as multiple organ failure (MOF). MOF is a dysfunctional systemic inflammatory response to trauma, which increases resource use, prolongs the patients critical care and hospital stay, causes late mortality and further complicates longer term recovery. Trauma care in the UK has improved since the implementation of trauma systems in April 2010. Severely injured patients are now taken to specialist centres for expert management. Studies in Australia and the USA suggest that this leads to a decrease in MOF however the incidence, severity and outcomes of MOF in the UK are yet to be described. The UK national trauma system is perfectly positioned to capture the current situation of organ failure in trauma patients admitted to critical care units. The information can help us to better understand the risks of MOF to potentially reduce the incidence, to accurately target resources and to improve the patient experience post injury.
REC name
London - Central Research Ethics Committee
REC reference
15/LO/1230
Date of REC Opinion
21 Aug 2015
REC opinion
Further Information Favourable Opinion