oRChiD: TRP Mechanisms Underlying Cough in Health and Disease
Research type
Research Study
Full title
oRChiD: The Role of Transient Receptor Potential (TRP) Channels in the Mechanisms Underlying Cough in Health and Disease
IRAS ID
181432
Contact name
Jaclyn Smith
Contact email
Sponsor organisation
University Hospital of South Manchester
Duration of Study in the UK
1 years, 0 months, 30 days
Research summary
Cough is a protective reflex which is used to clear the airways of irritating material or phlegm and yet it is the most common complaint for which people seek medical advice. Cough is a common feature of a number of different chest conditions and can be troublesome and associated with poor quality of life.
Current cough medicines often fail to help people with cough because the reasons that a cough develops are poorly understood.
We are doing this research to help us understand why people with different chest conditions develop cough and how their cough compares with healthy individuals. In this study we aim to recruit 100 participants; 20 healthy controls, 20 asthma patients, 20 chronic obstructive pulmonary disease (COPD) patients, 20 idiopathic pulmonary fibrosis (IPF) patients, and 20 chronic cough patients. Each group will be split into 10 males and 10 females. Participants will be recruited from the University Hospital of South Manchester. The patients with chest conditions will not be intentionally matched by age or gender to the healthy controls in order to achieve representative cohorts. The participants will undergo 5 cough challenges at 2-7 day intervals with various cough challenge solutions.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
15/NW/0726
Date of REC Opinion
15 Feb 2017
REC opinion
Further Information Favourable Opinion