ORBITA-MOON
Research type
Research Study
Full title
Multivessel balloon Occlusion to investigate Obstructive coronary artery disease and aNgina.
IRAS ID
334816
Contact name
Rasha Al-Lamee
Contact email
Sponsor organisation
Joint Research Compliance Office, Imperial College London
Duration of Study in the UK
2 years, 11 months, 28 days
Research summary
Many patients suffer from angina (chest pain on exertion), usually caused by narrowings of the coronary arteries. Many people with angina have multivessel disease - multiple narrowings (stenoses) involving more than one of their coronary arteries. It is not well understood, why some narrowings cause angina and why some do not. It has been thought that the more visually severe the narrowing, or the more limited the blood flow is down the artery, the more likely you are to have angina. However recent studies have shown this is not always the case. We also assume that within the same patient, the stenoses which are visually severe or are supplying the largest amount of heart muscle, cause more angina and so should be treated. However, this has never been studied before.
For the first time, with this NIHR funded project, I will study the difference in symptoms caused by different narrowings in the same patient. I want to understand what qualities make some coronary narrowings cause pain and others not.
I will recruit patients who are planned for stenting to multiple narrowings. Just prior to stenting, we will perform blinded experiments in which we will either inflate a balloon across the narrowing for a few seconds to induce angina, or perform a placebo inflation in which no balloon will be inflated. We will then record the nature and severity of pain caused at each narrowing. Using these data, I will study if there is a difference between the angina caused by different narrowings within the same patient, and which factors predict angina.
If successful, my work will help doctors to decide which stenoses to treat to improve patient symptoms and allow us to target stenting to those who will have the most benefit and avoid unnecessary procedures in patients with little to gain.
REC name
London - Queen Square Research Ethics Committee
REC reference
24/LO/0230
Date of REC Opinion
3 Apr 2024
REC opinion
Favourable Opinion