Oral formulations targeting periodontitis in Type 2 Diabetics

• Research type

  Research Study

• Full title

  Oral microflora in patients with Type 2 diabetes and their response to oral formulations targeting periodontal complications.

• IRAS ID

  282236

• Contact name

  Saliha Saad

• Sponsor organisation

  University of the West of England

• Clinicaltrials.gov Identifier

  n/a, n/a

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  Periodontitis (gum disease) is a common, complex, highly prevalent chronic condition of global significance and can affect any individual during their life, causing a lot of distress and in some cases, could lead to tooth loss. Periodontitis may arise from microbes on the gum and can be recovered from the surface of the tongue. It is believed that certain types of microbes have the capacity to transform certain substrates into odiferous gases. By measuring breath levels and sampling the gum and tongue-scrape for the numbers and types of microbes, an association may be seen between breath odor and quantity or types of microbes present on the gum and on the surface of the tongue. This study will also focus on the analysis of the oral microbiota profile from the mouths of individuals of Caucasian origin and African origin. Also, this study aims to address the response of the oral microflora to selected oral formulations developed by Colgate-Palmolive, which is particularly important for influencing the development of oral hygiene formulations (e.g. mouthwashes, lozenges, or toothpaste) that could be potentially used to reduce gum disease which may be contributing to systemic diseases such as diabetes.
  

• REC name

  London - Bromley Research Ethics Committee

• REC reference

  22/LO/0134

• Date of REC Opinion

  25 Feb 2022

• REC opinion

  Unfavourable Opinion