ORal antibiotics Instead of IntraVenous Antibiotics (ORIIVA)

• Research type

  Research Study

• Full title

  ORal antibiotics Instead of IntraVenous Antibiotics (ORIIVA): Developing computer software that can inform antibiotic prescribers when oral antibiotics are equivalent to intravenous antibiotics.

• IRAS ID

  223955

• Contact name

  Andrew Kirby

• Contact email

  a.kirby@leeds.ac.uk

• Sponsor organisation

  University of Leeds

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  The preparation and delivery of intravenous antibiotics uses lots of nursing time, requires patients to have multiple cannulas inserted and promotes the use of broad spectrum antibiotics which increases antibiotic resistance. About 45 million doses of intravenous antibiotics are prescribed each year in England.

  Qualitative research found doctors prescribe intravenous antibiotics because antibiotics administered intravenously were associated with “mythical properties” likely to make them more effective. This is likely to be because doctors are not trained to be able to compare how effective an oral antibiotic is in relation to an intravenous antibiotic, nor do they have a tool to help them do this.

  There have been trials in which oral antibiotics have been compared to intravenous antibiotics. A completed NIHR funded trial compared oral to intravenous antibiotics for the treatment of bone infections. This showed no difference in outcomes between the groups. The option now is to undertake clinical research studies comparing oral antibiotics to intravenous antibiotics for all infections, caused by all bacteria, and to be treated by all antibiotics, or to create a single tool which will be able to support doctors in prescribing oral antibiotics across a wide range of bacterial infections.

  We intend to
  • Develop prototype computer software to support doctors in the prescribing of antibiotic therapy-antibiotic dosing Decision Support Software (adDSS). This software will let doctors know when an oral antibiotic would be predicted to be as effective as an intravenous antibiotic.
  • Undertake a non-interventional clinical study where we will collect samples from patients to assess how well this software works at predicting:
  o concentrations of antibiotic in patients blood
  o how often oral antibiotics are predicted to be as effective as intravenous antibiotics

• REC name

  East of England - Cambridgeshire and Hertfordshire Research Ethics Committee

• REC reference

  17/EE/0393

• Date of REC Opinion

  4 Oct 2017

• REC opinion

  Further Information Favourable Opinion