Optimising HFO&VTV in newborn infants
Research type
Research Study
Full title
Crossover study of the cerebral blood flow and cardiac output at different targeted tidal volumes during high frequency oscillation with volume targeted ventilation (HFO&VTV)
IRAS ID
349734
Contact name
Ourania Kaltsogianni
Contact email
Sponsor organisation
King's College Hospital
Duration of Study in the UK
1 years, 6 months, 0 days
Research summary
Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications. High frequency oscillation (HFO) is a type of MV that delivers small volumes of gas across the lungs at fast frequencies. HFO is a lung protective strategy but it has also been linked to brain injury due to low carbon dioxide tensions. High-frequency oscillation with volume-targeted ventilation (HFO&VTV) is a new mode of HFO in which the clinician sets a target volume of gas to be delivered to the lungs at fast rates to decrease the lung injury related to the ventilator. Further, HFO&VTV achieves better control of carbon dioxide levels and may therefore protect against brain injury. Currently, there are no written guidelines about the use of HFO&VTV.
We aim to determine the safety profile of HFO&VTV compared to HFO by comparing the velocity of blood flow to the brain in term born infants and the cardiac output in term and preterm infants during the two modes. We will also determine the optimum starting value of the target tidal volume during HFOV&VTV. Infants will be studied at three different target tidal volumes for a period of 10-20 minutes each. A cranial ultrasound (for term infants only) and bedside echocardiogram will be performed at the end of each period.REC name
London - Hampstead Research Ethics Committee
REC reference
25/LO/0026
Date of REC Opinion
25 Feb 2025
REC opinion
Further Information Favourable Opinion