Optimising detection of cognitive decline and associated symptoms

• Research type

  Research Study

• Full title

  Optimising detection of cognitive decline and associated symptoms

• IRAS ID

  244064

• Contact name

  Annalena Venneri

• Contact email

  a.venneri@sheffield.ac.uk

• Sponsor organisation

  Sheffield Teaching Hospitals NHS Foundation Trust

• Duration of Study in the UK

  4 years, 11 months, 31 days

• Research summary

  The main aim of this study is to optimise procedures for early detection of cognitive decline and associated predictive symptoms (cognitive and behavioural). To this end a combination of neuroimaging, cognitive and genetic evidence will be used to test the optimal procedures that allows the best detection of early cases of cognitive decline due to Alzheimer's disease. The procedures to be tested will include stratification by APOE genotype (a genetic risk factor for the sporadic form of Alzheimer's disease), by cognitive profile (according to level of performance of tests of declarative memory, social cognition and executive functions) and neuroimaging (degree of regional atrophy in mediotemporal complex structures and posterior cingulate). If successful this project can be translated into immediate clinical application.

• REC name

  West of Scotland REC 5

• REC reference

  19/WS/0177

• Date of REC Opinion

  15 Nov 2019

• REC opinion

  Favourable Opinion