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Optimising detection of cognitive decline and associated symptoms

  • Research type

    Research Study

  • Full title

    Optimising detection of cognitive decline and associated symptoms



  • Contact name

    Annalena Venneri

  • Contact email

  • Sponsor organisation

    Sheffield Teaching Hospitals NHS Foundation Trust

  • Duration of Study in the UK

    4 years, 11 months, 31 days

  • Research summary

    The main aim of this study is to optimise procedures for early detection of cognitive decline and associated predictive symptoms (cognitive and behavioural). To this end a combination of neuroimaging, cognitive and genetic evidence will be used to test the optimal procedures that allows the best detection of early cases of cognitive decline due to Alzheimer's disease. The procedures to be tested will include stratification by APOE genotype (a genetic risk factor for the sporadic form of Alzheimer's disease), by cognitive profile (according to level of performance of tests of declarative memory, social cognition and executive functions) and neuroimaging (degree of regional atrophy in mediotemporal complex structures and posterior cingulate). If successful this project can be translated into immediate clinical application.

  • REC name

    West of Scotland REC 5

  • REC reference


  • Date of REC Opinion

    15 Nov 2019

  • REC opinion

    Favourable Opinion