Optimal device therapy for heart failure using computer decision aid
Research type
Research Study
Full title
Mathematical analysis of heart rate variability in patients with moderate symptoms of heart failure, enabling the identification of a good prognostic group and potentially allowing device therapy (biventricular pacemakers with or without defibrillators) to be targeted to the high risk sub-population making treatment of these individuals more cost effective.
IRAS ID
99329
Contact name
Samir Srivastava
Contact email
Sponsor organisation
Royal Liverpool and Broadgreen University Hospitals Trust
Research summary
Heart failure is common and is set to become increasingly prevalent. We know that cardiac resynchronisation therapy (CRT), a special form of pacemaker, reduces symptoms and lengthens life in those exhibiting significant symptoms but because of the cost, is currently limited to only those with severe symptoms, despite recent evidence that some patients with milder symptoms benefit. We aim to develop and validate a computer based model which will allow us to identify those people with lesser degrees of heart failure who would be most likely to benefit, thus making it cost effective to offer those patients this therapy. A key clinical parameter being measured is heart rate variability, which has been proven to be useful in identifying prognostic differences between patient groups with chronic heart failure
REC name
North West - Preston Research Ethics Committee
REC reference
13/NW/0544
Date of REC Opinion
21 Oct 2013
REC opinion
Further Information Favourable Opinion