oesophageal-gastric junction and its clinical implications in reflux
Research type
Research Study
Full title
Oesophageal gastric junction (OGJ) pressure characteristics and its clinical implications in reflux
IRAS ID
233337
Contact name
Helena Gorick-Hennessey
Contact email
Sponsor organisation
Leeds Teaching Hospital NHS Trust
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Oesophageal high resolution manometry is an investigation measuring the pressure within the gullet to look at its motility and the valve between the stomach and gullet. This valve is made up of two parts, the lower oesophageal sphincter and the crural diaphragm. The valve squeezes tightly and acts as a barrier to stop stomach acid coming up into the gullet. This can cause irritation and heartburn symptoms. Sometimes these two parts separate when part of the stomach pushes up through the valve and into the chest, this is called a hiatus hernia. Hiatus hernias can result in an increased risk of heartburn. Many improvements and advances have been made to high resolution manometry, allowing more information to be gained from the test. Many research studies have been carried out using this test to look for patterns in the gullets anatomy and different types of hiatus hernia depending on the size. Studies have also shown a link between heartburn and the size of hiatus hernias. However there are no studies to show the best way of measuring the length and pressure of the valve. This study is going to see if the level of reflux is associated with the size of separation of the two parts of the valve and therefore to look at the where the pressure and length of the valve should be measured from.
REC name
North of Scotland Research Ethics Committee 1
REC reference
18/NS/0039
Date of REC Opinion
26 Mar 2018
REC opinion
Favourable Opinion