OE-MRI to distinguish acute and chronic hypoxia
Research type
Research Study
Full title
Evaluation of Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI) for mapping and differentiation of acute and chronic hypoxia in tumours.
IRAS ID
312101
Contact name
James O'Connor
Contact email
Sponsor organisation
The Royal Marsden NHS Foundation Trust
Duration of Study in the UK
2 years, 6 months, 1 days
Research summary
Oxygen-enhanced magnetic resonance imaging (OE-MRI) is a technique where normal and low oxygen, regions of tumour can be identified and spatially mapped.
The aim of this research study is to develop non-invasive methods to differentiate between acute and chronic low oxygen, termed hypoxia, regions of tumour. This will help to better understand hypoxia related drug resistance and develop new therapies, where treatment is delivered according to the spatial distribution of each kind of hypoxia
The study will be conducted in cancer patients with head and neck or pelvic cancer and volunteers at The Royal Marsden NHS Foundation Trust.
All patients and healthy volunteers will undergo a 40-45 minute MRI scan in each session which will include an OE-MRI scan while breathing air or pure oxygen. All participants will undertake one or more MR examination(s), which will be in addition to any routine clinical examinations for the patients. The examination will involve breathing medical air (21% oxygen) or pure oxygen through a face mask during the scanning. The gas required for the OE-MRI scanning will be administered via a facial mask. Patient volunteers will also undergo a dynamic contrast enhanced (DCE) scan using an injection of gadolinium based contrast agent used in routine clinical care. The study will not make any changes to patients’ standard of care treatment.
A total of 60 patients and volunteers will be recruited to this study over 2.5 years.REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
22/NW/0365
Date of REC Opinion
24 Jan 2023
REC opinion
Further Information Favourable Opinion