OCTOPUS study
Research type
Research Study
Full title
Optical Coherence Tomography in Out Patient dermatology UnitS (OCTOPUS) study
IRAS ID
351678
Contact name
Catherine Harwood
Contact email
Sponsor organisation
Barts Health NHS Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
This study aims to investigate the clinical accuracy of two CE-marked non-invasive imaging devices: optical coherence tomography (OCT) and line confocal optical coherence tomography (LC-OCT) in the assessment of skin lesions and the extent to which it can be used to reduce the need for a diagnostic biopsy and its associated clinical and resource costs. Participants will follow their normal clinical and surgical pathway and those with relevant lesions will be scanned in advance of their procedure. The histopathological diagnosis following their surgery will be compared to the diagnosis obtained by the imaging modalities. The comparison will allow us to understand the accuracy of the optical coherence tomography in assessing skin lesions, and the extent to which this can be used to reduce the diagnostic need for an invasive skin biopsy and reduce time to diagnosis and treatment.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
25/ES/0097
Date of REC Opinion
27 Jan 2026
REC opinion
Further Information Favourable Opinion