OCT-RISK
Research type
Research Study
Full title
Optical coherence tomography with magnetic resonance angiography to assess STEMI non-culprit risk
IRAS ID
292740
Contact name
Matthew Li Kam Wa
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
4 years, 5 months, 30 days
Research summary
Heart attacks are caused when an artery supplying blood becomes blocked. They are treated with an emergency procedure to open the artery using a small metal tube (angiogram with a stent). During this procedure, we will discover that most people also have ‘non-culprit’ narrowings in their other heart arteries. If severe, these are often also treated with stents. However, we know that the severity of a narrowing alone may not the best way to decide what to treat. This is because mild narrowings can rapidly progress and not all severe narrowings will lead to a heart attack. A better way to predict which narrowings need treatment and which can be left alone is needed.
Optical coherence tomography (OCT) is a device that can scan the heart artery during an angiogram. Magnetic resonance angiography (MRA) is a non-invasive scan of the heart arteries, with recent advances meaning that it can be done faster and in higher detail than ever before. Both techniques provide more information than just the angiogram alone. We believe that they can be used to understand in detail how blood behaves around non-culprit narrowings, better understand how these narrowings progress, and predict which are likely to cause heart attacks in the future.
We are asking people in hospital after a heart attack who are due to have an angiogram for non-culprit narrowings, to also have flow and OCT measurements made inside their heart arteries. They will also have a MRA before going home. The angiogram and MRA will be repeated in 6 months and the MRA again at 36 months. This information will be used to see if the OCT or MRA can predict which narrowings will cause problems in the future, so that we can better tailor treatment to people after a heart attack.
REC name
London - Dulwich Research Ethics Committee
REC reference
23/LO/0045
Date of REC Opinion
6 Feb 2023
REC opinion
Further Information Favourable Opinion