OCT guided distal cell recrossing
Research type
Research Study
Full title
OCT guided distal cell recrossing: a randomised comparison with angiograpy alone in bifurcational lesions treated with second generation stents
IRAS ID
119950
Contact name
Carlo Di Mario
Contact email
Sponsor organisation
Royal Brompton & Harefield NHS Foundation Trust
Research summary
The aim of this project is to improve the treatment of complicated coronary artery disease lesions or narrowings, which specifically occur at the junction where two coronary arteries branch or diverge. This includes a main artery and a smaller side-branch artery, called a bifurcation lesion. This lesion type is commonly found in 15-20% of patients with ischemic heart disease. Although the generally accepted technique used to treat and open these narrowings is deployment of a single stent (metallic mesh-like hollow tube), there remains some technical issues with this treatment which have not yet been clarified. In this scientific study we aim to examine these through the use of Optical Coherence Tomography (OCT).
This new imaging (scanning) light-based technique consisting of a small fibre-optic wire, allows us to acquire high resolution images of the inside lining of coronary arteries. It is performed at the same time as the Percutaneous Coronary Intervetion (PCI) procedure, taking less than 5 seconds to image an entire artery. This tool will be used to guide the best placement of stents according to two different technical approaches, in patients undergoing elective bifurcation stenting. 40 patients will be randomised into two groups. Treatment Group 1 will receive the OCT guided stenting technique. Control Group 2 will receive the non-guided or standard stenting technique followed by OCT, for observation or documentary procedural evidence only. We aim to demonstrate the difference in technical results between the two groups.
Secondary endpoints will be the assessment of acute complications (death, myocardial infartion) and patient relevant outcomes at 1 year follow up.REC name
London - Chelsea Research Ethics Committee
REC reference
13/LO/0127
Date of REC Opinion
22 May 2013
REC opinion
Further Information Favourable Opinion