Obtaining antibodies from kidney transplants. Version 1
Research type
Research Study
Full title
The development of an assay to elute anti-HLA antibodies from kidney transplant material.
IRAS ID
179469
Contact name
Abdelqadar Hammad
Contact email
Sponsor organisation
Liverpool Health Partners Joint Research Office
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
In our hospital, we perform specialised tests on blood samples from patients who have received a kidney transplant to see if any antibodies have developed against the transplant. We would like to develop a technique to be able to extract antibodies from the kidney transplants themselves, so that we can perform similar tests to detect antibodies. Other studies have shown that the presence of antibodies in the tissue sample may lead to worse outcomes for the kidney, than is the antibodies are only present in blood. Thus, in the long term, we would like to use the method we develop to obtain antibodies from transplant biopsies which we perform when the kidney is not functioning well which may ultimately allow us to better tailor the treatment offered to a patient undergoing rejection. In order to proceed to this stage, we need to develop and validate an assay for obtaining the antibodies from kidney tissue and we propose using samples taken from transplanted kidneys, that are being removed.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
15/NW/0692
Date of REC Opinion
10 Sep 2015
REC opinion
Further Information Favourable Opinion