Observer performance and image qualty in low-dose CT.
Research type
Research Study
Full title
Task-specific observer performance and image quality: direct and indirect relationships in low-dose CT images.
IRAS ID
173535
Contact name
LM Maryam Jessop
Contact email
Duration of Study in the UK
1 years, 8 months, 30 days
Research summary
Low-dose computerized tomography (LDCT) is now used in a variety of settings, where in combination with improved CT technology, image quality is sufficient to see abnormalities while the patient receives the lowest dose possible. Understanding technical limitations is important when reporting these LDCT images, but investigations looking at how well we see these abnormalities, and other image evaluation methods, are showing that detection and image quality do no always correspond.
The aim of the research is to determine quantifiable relationships between image characteristics and how well we see image features and lesions in a low-dose CT image. After using appropriate measures of image characteristics and measuring how well an observer sees image features and lesions in these images, the results will then undergo robust statistical analyses to quantify any direct or indirect relationships.
Simulation image data (acquired at varying amperage settings affecting image quality) will provide the basis for establishing image quality analysis and measurements of what an observer sees. Anonymised patient data will also be used from existing clinical images, in particular for areas of low CT contrast such as the abdomen or soft tissue in the neck (where suitable body facsimiles for imaging are currently not available). Histology results will also be obtained for image correlation. This research is expected to be carried out over the next 2 years, using both NHS and university facilities.
REC name
London - City & East Research Ethics Committee
REC reference
15/LO/0739
Date of REC Opinion
21 Apr 2015
REC opinion
Favourable Opinion