Objective Measurement of Eyelid Margin Lissamine Green Staining
Research type
Research Study
Full title
Objective Measurement of Eyelid Margin Lissamine Green Staining
IRAS ID
198116
Contact name
Michel Guillon
Contact email
Sponsor organisation
OCULAR TECHNOLOGY GROUP - International
Duration of Study in the UK
0 years, 11 months, 28 days
Research summary
Friction between the underside edges of the upper and lower eyelids and the anterior ocular surface (or contact lens) during the blink can result in transient damage to these areas of the eyelids. Clinically this is assessed with the aid of ophthalmic dyes, which temporarily stain the area, and the observer subjectively grades the appearance of the staining. Our research group has developed a clinical methodology to photograph the staining of the eyelid margin under controlled conditions and to automatically analyse the photographs in order to produce an objective measurement of the extent of staining that is present.
The purpose of this investigation is to validate this technique by comparing the automated analysis results to the manual detection of the staining captured on a series of representative photographs, and to measure the repeatability of the technique. In addition the resolution of the objective measurement will be compared with subjective grading by trained observers.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
16/EM/0021
Date of REC Opinion
12 Jan 2016
REC opinion
Unfavourable Opinion