ObeSity related Colorectal Adenoma Risk
Research type
Research Study
Full title
ObeSity related Colorectal Adenoma Risk
IRAS ID
189914
Contact name
Sara Koo
Contact email
Sponsor organisation
South Tyneside NHS Foundation Trust
Duration of Study in the UK
1 years, 6 months, 29 days
Research summary
In the UK, around 1 in 16 men and 1 in 20 women will develop bowel cancer at some point in their lives. Most bowel cancers happen when a type of growth in the bowel called an adenoma eventually becomes cancerous. Cutting out adenomas reduces the risk of developing bowel cancer.
Certain people are more likely to have adenomas than others, for example people who are overweight. People who are overweight are also more likely to develop liver disease by laying too much fat down in the liver. Studies in Asia have shown that people with fatty liver disease are more likely to have adenomas and these are more commonly found in the part of the bowel (right colon) furthest from the bottom end.
Information on the link between obesity, fatty liver disease and adenomas is very limited, particularly in the Western population.
We will assess the link between body weight, fatty liver and adenomas in the UK population. We will invite 1430 patients; some through the bowel cancer screening programme and some with symptoms such as low blood count, bleeding or changed bowel habit. These patients will already have been referred for a camera test looking into the bowel, called a colonoscopy. We will collect information including height, weight and some health questions. Blood samples will be taken. We will compare the number of patients with adenomas who have liver disease or who are overweight with those who don't. This information will be used to develop a scoring system to predict risk of adenomas. This will help us decide if undertaking colonoscopies in these patients will identify those at increased risk of bowel cancer.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
17/LO/1746
Date of REC Opinion
14 Oct 2017
REC opinion
Favourable Opinion