Ob-AKI feasibility study
Research type
Research Study
Full title
The impact of obesity on recovery from acute kidney injury (AKI): the Ob-AKI feasibility study
IRAS ID
178174
Contact name
Helen MacLaughlin
Contact email
Sponsor organisation
King's College Hospital NHS Foundation Trust
Duration of Study in the UK
1 years, 7 months, 2 days
Research summary
One in every 20 people hospitalised experience acute kidney injury (AKI) – when the kidneys stop working. Recovery from the more common mild-to moderate forms of AKI was previously thought to have no long-term effects. Newer research shows that people who have AKI are more likely to develop permanent kidney damage, or chronic kidney disease (CKD). Obesity increases the risk for AKI, but it’s not known if obesity changes the risk for future CKD.
The relationship between obesity, recovery from AKI, and later development or progression of CKD will be studied in 100 participants over 1 year to determine if a larger study is possible. Patients will be recruited and consented whilst an inpatient with AKI or just after discharge. Baseline data collection including measured height, weight, waist circumference, blood pressure, baseline kidney function, blood and urine samples, other medical conditions, and dietary assessment (interview and questionnaires) will occur within 4 weeks after discharge. Follow up data collection of blood pressure, blood and urine samples will occur at hospital study visits 3, 6, and 12 months after the episode of AKI.
Rates of recruitment, retention and completion of data collection will be described and analysed to assess the feasibility of recruitment to a larger study. The rates of AKI in obese and non-obese groups will be defined. The number of new cases of CKD or CKD progression after AKI in obese and non-obese groups will be described. All this data will be used to determine whether a full study to investigate the effect of obesity on progression to CKD after AKI is practical, feasible and warranted.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
15/LO/0907
Date of REC Opinion
8 Jun 2015
REC opinion
Favourable Opinion