OatMet version 2
Research type
Research Study
Full title
The effect of oat processing on gastric emptying and satiety induced after consuming porridge.
IRAS ID
166138
Contact name
Alan Mackie
Contact email
Sponsor organisation
Institute of Food Research
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
OatMet is a two-way randomised crossover study, where the rates of gastric emptying of 2 different types of porridge, prepared from oats processed in 2 different ways, (finely milled or flaked oats) will be matched to levels of glucose, insulin, key gastrointestinal (GI) hormones in the blood and feelings of fullness and satiety; to provide information about how the structure of processed oats affects some of the mechanisms that regulate appetite and satiety.
The study will include a total of 8 participants, who meet the basic inclusion criteria: male, apparently healthy, aged 20-55 years, BMI between 19-30 kg/m2. Each participant will take part in 2 study days (min. of 7 days break between the 1st and 2nd study day). On each study day they will consume 264 g of porridge with 175 ml water to drink.
To assess gastric layering and emptying rates, 9 MRI (magnetic resonance imaging) scans (per study day) of the participant’s stomachs, each lasting no longer than 5 min, will be taken. The first at 15 min pre-meal (baseline) and 8 post-meal at: 5, 25, 45, 65, 90, 115, 145 and 180 min.
In order to determine changes in concentrations of circulating glucose, insulin and key GI hormones (ghrelin, cholecystokinin, glucagon-like peptide-1, gastric inhibitory polypeptide and peptide YY), 4 ml blood samples will be taken via an intravenous cannula at the following time points: one pre-meal (10 min before consumption of the porridge) (baseline) and then at 10, 20, 35, 60, 85, 110, 140 and 170 min (9 samples).
Feelings of hunger and thirst will be monitored by a short questionnaire; to be completed at the following times: one pre-meal (5 min before consumption of the porridge), and then at 15, 30, 50, 70, 100, 130, 160 and 190 min (9 questionnaires).
REC name
South West - Frenchay Research Ethics Committee
REC reference
15/SW/0165
Date of REC Opinion
27 May 2015
REC opinion
Favourable Opinion