Nurse-led Optos screening for Retinopathy of Prematurity
Research type
Research Study
Full title
Feasibility of nurse-led retinal imaging for retinopathy of prematurity screening using the Optos California
IRAS ID
285342
Contact name
Shalini Ojha
Contact email
Sponsor organisation
University of Nottingham
Duration of Study in the UK
1 years, 6 months, 4 days
Research summary
Research summary
Retinopathy of prematurity (ROP) is a preventable cause of blindness in babies who are born early i.e. premature. Internationally, there is a shortage of skilled ophthalmologists willing and able to screen for ROP. Even in the UK, not all hospitals have skilled ophthalmologist and premature babies have to travel to other hospitals, often long distances, to have their eyes examined. As a missed examination can lead to sight loss, this is burden for families and carers of premature babies. To fill this gap, previous studies have explored the use of non-ophthalmologists health care workers to increase the workforce screening for ROP.
Recently, the Optos ultra-widefield retinal-imaging device (Optos PLC, Dunfermline, Scotland, UK) has been used to help document different stages of ROP in infants. This specialised retinal imaging system uses an internal ellipsoid mirror to capture fundal imaging angles of up to 200-degrees, or more than 80% of the entire retina, in a single image. A single retinal image can be acquired in a quarter of a second and are automatically captured when the infant’s pupils are aligned with the Optos imaging device. No contact with the eye is necessary to capture an image of the retina. To date there are no studies that have validated the Optos as a nurse-led screening tool for ROP.
We would like to conduct a prospective study to determine and validate the feasibility of neonatal nurse-led retinal imagers for ROP screening employing the Optos imaging device. The main purpose of this study will be to test if it is possible for trained nurses to take good images of of the back of babies eyes (retina) and if these images can be used by remotely placed ophthalmologists to diagnose and grade ROP. We will compare how good the diagnosis and grading done using Optos images are compared to the current gold standard method (BIO). We will also test how much agreement there is between ophthalmologists in interpreting Optos images by asking two ophthalmologists to grade the images.Lay summary of study results
Nurse-led Optos photo screening had insufficient sensitivity to be recommended as a substitute for binocular indirect ophthalmoscopy in screening for Retinopathy of Prematurity. Optos imaging should be regarded as an adjunct to, rather than a replacement for binocular indirect ophthalmoscopy in Retinopathy of Prematurity screening.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
20/EE/0256
Date of REC Opinion
27 Nov 2020
REC opinion
Further Information Favourable Opinion