Novel Vascular Manifestations of COPD 2
Research type
Research Study
Full title
Novel Vascular Manifestations of COPD 2 (NoVasc 2)
IRAS ID
169485
Contact name
Emma Baker
Contact email
Sponsor organisation
Joint Research & Enterprise Office St George's, University of London and St George's University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease, usually caused in the UK by smoking tobacco, which causes shortness of breath and exercise limitation. People with COPD are more likely to have heart disease and strokes than people who smoke who do not have COPD.
The Novel Vascular Manifestations of COPD 2(NoVasc 2) study is designed to improve our understanding of how COPD may affect other parts of the body including the brain, heart, eyes and kidneys. People who have known disease of the large blood vessels (macrovascular disease) detected by imaging the arteries supplying the heart (coronary angiography) will be invited to take part in the study. Participants will be recruited in 2 groups, with and without COPD, and will be matched for smoking history. The main objective of our study is to find out whether people with COPD have more damage to their small and microscopic blood vessels than those without COPD
All investigations will be performed at St George's Hospital in the clinical research facility. Participants will attend for a single day visit. Research procedures to assess the large, small and microscopic blood vessels will include: blood tests; a breathing test (spirometry); a scan of microscopic vessels in the skin surface (capillaroscopy); measurement of large blood vessel stiffness (pulse wave velocity); a photograph of the back of the eye to look at retinal vessels; and a magnetic resonance image (MRI) scan of the brain. Using these tests, vascular structure and function will be compared between people with and without COPD, matched for macrovascular disease and smoking history.REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
15/EM/0425
Date of REC Opinion
14 Oct 2015
REC opinion
Further Information Favourable Opinion