Novel strategies to enhance xenobiotic penetration into the skin
Research type
Research Study
Full title
Novel strategies to enhance xeonbiotic penetration into the skin
IRAS ID
225127
Contact name
Stuart Jones
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
The administration of chemicals to the skin for therapeutic benefit is highly desirable, however the barrier properties of the skin make the entry of topically applied agents problematic. In order to facilitate the entry of therapeutic agents into the skin it is desirable to develop novel penetration enhancing systems. These systems can be chemical approaches that modify the therapeutic agents or skin barrier to facilitate entry into the dermal tissue. Alternatively they can be physical devices which perturb the skin. In this research project we will investigate how mechanical stretching of the skin alters its barrier properties and how this can facilitate penetration enhancing techniques to drive chemicals into the tissue during skin stretching. We will use surplus skin obtained from elective surgery in an ex-vivo model to perform these investigations.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
17/SC/0441
Date of REC Opinion
1 Sep 2017
REC opinion
Further Information Favourable Opinion