Novel SERS-based Technology for the Early Detection of Skin Cancer
Research type
Research Study
Full title
Novel Portable Technology for Early-Stage Dermatological Cancer Diagnostics using Hybrid Surface Enhanced Raman Spectroscopy and Machine Learning Platform
IRAS ID
336270
Contact name
Pola Goldberg Oppenheimer
Contact email
Sponsor organisation
Head of Research Governance and Integrity
Duration of Study in the UK
2 years, 11 months, 20 days
Research summary
The study aims to develop a novel portable technology utilizing Surface-enhanced Raman spectroscopy (SERS) for the early-stage detection of dermatological cancer. The study involves the integration and optimization of SERS technology, validation of biomarker sensitivity, and the development of a portable micro-engineered system. Clinical samples consisting of venous blood plasma will be collected from participants by a registered clinician or nurse according to eligibility criteria. Those blood samples will be then transported to the department of Chemical Engineering (University of Birmingham), where further studies and analysis will follow. Plasma (obtained by centrifuging at 1200 x g for 10 mins) samples will be subjected to SERS analysis using appropriate parameters. Data analysis will involve untargeted analysis and statistical modelling, including descriptive statistics and classification models. Results will contribute to the understanding of skin cancer progression, early detection, and better clinical management. The participants include Healthy cohort (n=50) and Cancer cohort (n=50).
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
25/YH/0028
Date of REC Opinion
13 Mar 2025
REC opinion
Further Information Favourable Opinion