Novel Markers of Acute Kidney Injury:Metabolomics analysis Ver 8.1
Research type
Research Study
Full title
Novel Markers of Acute Kidney Injury: Metabolomics analysis, Ver 8.1
IRAS ID
163337
Contact name
Kolitha Basnayake
Contact email
Sponsor organisation
Brighton and Sussex University Hospital NHS Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Acute kidney injury (AKI) affects 18% of all UK hospital admissions, leading to an increase in mortality in hospital inpatients. Recognition and early intervention is increasingly recognised as the cornerstone of treatment. Current diagnostic criteria focus upon rises in creatinine and decreases in urine output. These events not only rely on recognition, but also by definition reflects a delay from insult to diagnosis though the time taken for serum creatinine to rise following renal injury. This delay highlights a therapeutic window in which intervention has the potential to improve and potentially change outcome.
This pilot study is designed to identify novel biological markers of renal stress which occur before the diagnostic criteria of AKI are met. By analysing the metabolomic profile (break down products of cellular activity ) in urine samples the study aims to identify markers which can be targeted in future clinical research. The study is designed to identify effective investigations to predict the likelihood of AKI progression. The potential benefits of identifying early renal cellular stress could provide an opportunity to provide intervention which could decrease patient morbidity and mortality.
The study aims to analyse timed urine and blood samples collected from a cohort of patients undergoing elective heart surgery. Participants would provide samples over a 72 hour period prior to and following the surgical intervention. Recruitment will be based in a single centre at the Royal Sussex County Hospital, Brighton & Sussex University Hospitals NHS Trust (BSUH), United Kingdom. The pilot study aims to recruit participants over a 6 month period.
Funding for consumables has been provided though the South Eastern Kidney Patients' Association: SEKPA(UK), registered charity no 284479. Independent Grant funding for scientific analysis of samples and funding for a research associate has been secured by The University of Sussex who will be undertaking the metabolomic sample analysis.REC name
East of Scotland Research Ethics Service REC 2
REC reference
15/ES/0143
Date of REC Opinion
11 Sep 2015
REC opinion
Unfavourable Opinion