Novel Cardiac PET-MR Acquisition and Reconstruction Techniques
Research type
Research Study
Full title
Development and Evaluation of Novel PET-MR Acquisition and Reconstruction Techniques for Improved Diagnosis of Heart Disease
IRAS ID
207592
Contact name
Amedeo Chiribiri
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
Coronary artery disease (CAD) is the leading single cause of morbidity and mortality in the Western world. CAD reduces the blood supply to the cardiac muscle and can lead to chest pain or heart attack. CAD is detected by a range of invasive and non-invasive tests. However in current practice a non-negligible number of patients that may not need the intervention are referred to invasive, ionizing, and potentially harmful x-ray cardiac catheterization procedures. Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) are very promising non-invasive tools for early risk assessment, guidance of therapy and treatment monitoring of CAD. Both technologies provide complementary information, thus the recent introduction of simultaneous PET-MR scanners offers great potential for accurate interpretation of findings of cardiac PET and MR images and new perspectives for more accurate and comprehensive CAD diagnosis and treatment, without the higher radiation exposure of PET-CT. Nevertheless, a number of technical challenges still prevent a widespread clinical use of this novel and promising imaging modality for cardiac imaging. In this study we aim to develop and evaluate novel methods to capture and process cardiac images using PET-MR hybrid scanners. This research study is foreseen as an important step towards wide spread clinical adoption of PET-MR cardiovascular imaging and lastly towards an efficient and accurate non-invasive assessment of CAD.
REC name
London - Fulham Research Ethics Committee
REC reference
17/LO/1794
Date of REC Opinion
20 Oct 2017
REC opinion
Favourable Opinion