Novel Biomarkers and Acute Kidney Injury post cardiac surgery
Research type
Research Study
Full title
The association of Novel Biomarkers and Acute Kidney Injury post cardiac surgery
IRAS ID
226168
Contact name
John Dark
Contact email
Sponsor organisation
NUTH
Duration of Study in the UK
0 years, 4 months, 5 days
Research summary
This research will address the question of whether novel biomarkers, small proteins that can be found in blood, can be used to predict and detect acute kidney injury (AKI) after heart surgery.
Some degree of AKI is common after cardiac surgery due to a number of factors, such as the use of the bypass machine and patient risk factors, such as age and the complexity of the surgery. Identification of patients with reduced kidney function, prior to standard blood test level changes, is a very aim worthwhile.
At present AKI is diagnosed by either the reduction in urine production or a rise of a chemical, creatinine, in the blood. Both of these measurements have problems in precisely diagnosing a kidney problem at an early stage. We will use a number of laboratory techniques, looking at some very promising new markers of kidney injury, called “microRNA’s” as well as some which have been used before. The research will provide valuable information surrounding the suitability of these biomarkers in the diagnosis of AKI and whether they are more effective than our current standard methods.
The area being studied is the evaluation of a new investigation of a disease.
The study will include adult patients who are undergoing cardiac surgery involving cardiopulmonary bypass.
The patients will be consented and samples collected at the Freeman Hospital with the lab work being carried out at Newcastle University.
The study will last 4-5 months and patients will only be asked to give a 10ml sample of blood and 20ml sample of urine from routinely placed bladder catheters and lines in blood vessels, before and 24hrs after their surgery.REC name
North West - Greater Manchester Central Research Ethics Committee
REC reference
18/NW/0279
Date of REC Opinion
8 May 2018
REC opinion
Further Information Favourable Opinion