Novel applications of 3D and Speckle tracking echocardiography
Research type
Research Study
Full title
Novel applications of three-dimensional (3D) and speckle tracking echocardiography (STE)
IRAS ID
178920
Contact name
Alexandros Papachristidis
Contact email
Sponsor organisation
King's College Hospital NHS Foundation Trust
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
The aim of this study is to evaluate new cardiac ultrasound techniques. We will compare that ability of echocardiography (cardiac ultrasound) to diagnose a scar on the heart muscle and will compare the results with cardiac magnetic resonance imaging (MRI).
Subsequently, we will assess how the scar in the heart muscle can affect the success of a special treatment which is offered to patients who have symptoms of heart failure. This treatment is delivered with a special cardiac pacemaker that is pacing the heart from different sites and is called cardiac resynchronization therapy (CRT). However, based on large trials this treatment does not provide significant benefit in about 30% of patients.
The patients who are scheduled for this sort of treatment are having an ultrasound scan of their heart as part of the work-up before treatment to assess their suitability. After treatment they are offered an ultrasound scan as well, as part of their follow-up. We are going to analyse the ultrasound images obtained before and after treatment with a novel software which allows detailed analysis of the mechanical function of the heart. We will then investigate whether the derived measurements can predict which patients are likely to respond to this treatment. All patients who will have this treatment will be eligible to participate in the trial.The participants will not undergo investigations other than those they routinely have as part of their work-up and follow-up. A proportion of them will be asked to undergo an additional ultrasound scan of the heart which is entirely safe and has neither contra-indications nor adverse effects.
The study will last approximately 2 years.REC name
West of Scotland REC 4
REC reference
15/WS/0186
Date of REC Opinion
8 Sep 2015
REC opinion
Further Information Favourable Opinion