Nottingham/Leeds Significant Ankle Ligament Injury (SALI) cohort
Research type
Research Study
Full title
Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury: the Nottingham/Leeds SALI cohort study.
IRAS ID
163091
Contact name
Debbie Palmer-Green
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
15 years, 0 months, 1 days
Research summary
Osteoarthritis (OA) is the most common joint disorder, and is a common cause of disability in adults in the Western World. Joint injury has been linked to the development of OA and while a lot of research has focused on injury and OA in the knee and hip, very little work has looked at the ankle, where around 80% of ankle OA is due to injury. Ankle sprains are common, accounting for up to 5% of all Emergency Department (ED) visits in the UK every year. They are often thought of, and treated as, minor injuries, and yet as many as half of people who suffer a severe ankle injury do not fully recover and end up with some lasting ankle problems that can limit the persons lifestyle. The purpose of this study is to provide new knowledge about:
1) The type of people who attend ED suffering a significant ankle ligament injury
2) What it is about those people and their injury that may mean they go on to develop OA
3) What things influence this chance i.e. who is more likely and who is less likely to go on to develop OA after a significant ankle ligament injuryParticipants will complete questionnaires at 7 time-points; at time of presentation to ED, and then at 3 months, 12 months, 3 years, 5 years, 10 years and 15 years post injury. In addition matched controls will be recruitment, completing the same questionnaires at each of the 7 time-points
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
15/EM/0384
Date of REC Opinion
5 Nov 2015
REC opinion
Further Information Favourable Opinion