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Nottingham/Leeds Significant Ankle Ligament Injury (SALI) cohort

  • Research type

    Research Study

  • Full title

    Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury: the Nottingham/Leeds SALI cohort study.



  • Contact name

    Debbie Palmer-Green

  • Contact email

  • Sponsor organisation

    Nottingham University Hospitals NHS Trust

  • Duration of Study in the UK

    15 years, 0 months, 1 days

  • Research summary

    Osteoarthritis (OA) is the most common joint disorder, and is a common cause of disability in adults in the Western World. Joint injury has been linked to the development of OA and while a lot of research has focused on injury and OA in the knee and hip, very little work has looked at the ankle, where around 80% of ankle OA is due to injury. Ankle sprains are common, accounting for up to 5% of all Emergency Department (ED) visits in the UK every year. They are often thought of, and treated as, minor injuries, and yet as many as half of people who suffer a severe ankle injury do not fully recover and end up with some lasting ankle problems that can limit the persons lifestyle. The purpose of this study is to provide new knowledge about:

    1) The type of people who attend ED suffering a significant ankle ligament injury
    2) What it is about those people and their injury that may mean they go on to develop OA
    3) What things influence this chance i.e. who is more likely and who is less likely to go on to develop OA after a significant ankle ligament injury

    Participants will complete questionnaires at 7 time-points; at time of presentation to ED, and then at 3 months, 12 months, 3 years, 5 years, 10 years and 15 years post injury. In addition matched controls will be recruitment, completing the same questionnaires at each of the 7 time-points

  • REC name

    East Midlands - Nottingham 1 Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    5 Nov 2015

  • REC opinion

    Further Information Favourable Opinion