Nottingham Health Science Biobank (NHSB)

• Research type

  Research Tissue Bank

• IRAS ID

  184265

• Research summary

  Nottingham Health Science Biobank (NHSB)

• REC name

  North West - Greater Manchester Central Research Ethics Committee

• REC reference

  15/NW/0685

• Date of REC Opinion

  18 Sep 2015

• REC opinion

  Favourable Opinion

• Data collection arrangements

  Shortterm "onsite" storage following collection of fresh snap frozen tissues and biological materials (ie fluid samples such as blood), and formalin fixed tissues, will be in the Department of Histopathology's premises at both Trust's hospitals; the Queens Medical Centre (QMC) and the Nottingham City Hospital (NCH).
  Long term storage of frozen tissues and biological materials will be in a designated central storage area. Long term storage of formalin fixed paraffin embedded tissues will be in the designated central storage area.
  All these premises are HTA licensed.
  Biomaterials that belong to the existing banks with the NUH NHS Trust and the UoN will be stored in their designated and previously approved storage facilities. However, there will be the opportunity to transfer these biomaterials to the
  central storage area to be archived according to our updated and standardised procedures to ensure that these materials are best served.
  All data (samples collection/consent and clinical data) will be stored on NHS servers and databases and will be accessible to NHS employees only or those who have been granted honorary contract status by NUH HR team.

• Research programme

  Any type of neoplastic, inflammatory, degenerative and other human disease related research projects will be eligible, involving existing and future techniques utilising tissue, body fluid, or processed products such as serum, plasma, DNA, RNA or protein. Databased research projects will also be supported by the NHSB. It is anticipated that research projects will include investigation of the epidemiology, pathogenesis, response to therapy and complications of a broad range of human disease conditions. It is anticipated that research may range widely across biomedicine and will include basic, translational (experimental medicine) and clinical research Tests to establish the presence of factors involved in disease aetiology, development, progression, behaviour and response to treatment. Also, assessment of the prognostic and predictive value of the well-established and novel biomarkers, testing treatment interactions and development of novel targeted therapies. Techniques will include traditional and newly developed assays such as immunohistochemistry, polymerase chain reactions, insitu hybridisation techniques, cell lines and functional assays, sequencing, cytogenetics, as well as large scale genome wide expression profiling studies including genomics, transcriptomics, metabolomics and proteomics. The ability to link sample information to clinical outcome data will provide powerful research tools and the data resulting from projects can be explored using bioinformatics to establish whether patterns exist. The NHSB access policy applies to academic, private or public sector researchers whether they work in, or with, a profit or not for profit organization. Researchers requesting samples from NHSB will be classified in one of four groups as follow: 1. Trust and UoN members contributing samples 2. Trust and UoN members non-contributing samples 3. External academic, non-commercial 4. Commercial

• Storage license

  12258

• RTBTitle

  Nottingham Health Science Biobank (NHSB)

• Establishment organisation

  Nottingham University Hospitals NHS Trust

• Establishment organisation address

  Nottingham University Hospitals NHS

  Trust, City Hospital campus

  Hucknall Road, Nottingham

  NG5 1PB