NORM PPCI
Research type
Research Study
Full title
NO Reflow PhenoMenon and comparison to the normal flow population post Primary Percutaneous Coronary Intervention for ST elevation myocardial infarction
IRAS ID
184221
Contact name
Jennifer A Rossington
Contact email
Sponsor organisation
Hull and East Yorkshire NHS Trust
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Heart attacks which present with particular heart tracing changes are a result of a clot completely blocking one of the hearts main blood vessels. This prevents the blood from delivering oxygen to the heart muscle, and can result in death of the heart muscle unless treated. The treatment recommended by the National Institute of Health and Care Excellence (NICE) is Primary Percutaneous Coronary Intervention (PPCI). This is the urgent procedure you underwent on admission and involves a wire, balloon and probable stent insertion into the blocked heart artery via a blood vessel in your arm or leg. The aim is to open the heart blood vessel (artery) and restore blood flow to the muscle.
In some cases despite opening up of the main heart vessel involved, the blood flow beyond the blockage is reduced which is a result of multiple processes; including clot travelling down the vessel, chemicals released by damaged cells and swelling of the surrounding muscle. This is known as no-reflow phenomenon.
Patients with this condition are at higher risk of heart muscle death, which can prevent the heart pump from working properly. There are treatments available to improve the flow but these are always provided after no-reflow phenomenon is seen during PPCI. Ideally preventative treatment would be optimum, however at present which patients are at the highest risk is not completely understood.
In this study we hope to gain a better understanding of no reflow phenomenon by looking at all patients presenting with heart attacks requiring PPCI. We plan to observe the frequency of no reflow phenomenon and compare multiple aspects of patient presentation, such as other medical complaints and features of the blockage, to see if we can find risk factors which would help us predict when it may occur.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
15/YH/0360
Date of REC Opinion
19 Oct 2015
REC opinion
Further Information Favourable Opinion