Norepinephrine response test

• Research type

  Research Study

• Full title

  Norepinephrine Response Test: Developing a Safe and Feasible Method of Measuring Cardiovascular Responsiveness in Critically Ill Mechanically Ventilated Patients

• IRAS ID

  254790

• Contact name

  Timothy Walsh

• Contact email

  timothy.walsh@ed.ac.uk

• Sponsor organisation

  University of Edinburgh

• Duration of Study in the UK

  0 years, 6 months, 30 days

• Research summary

  We aim to devise a safe and feasible clinical method of determining a patient's cardiovascular responsiveness to exogenous norepinephrine. This will be done in a single centre Intensive Care Unit, recruiting patients with a primary diagnosis of septic or inflammatory shock. These patients will be sedated, and mechanically ventilated with a norepinephrine requirement to support blood pressure. We aim to recruit 30 patients over a period of 6 months. Devising this clinical method will allow us to, in future studies, find management strategies that overall improve the cardiovascular responsiveness of patients with septic or inflammatory shock.

• REC name

  Scotland A: Adults with Incapacity only

• REC reference

  19/SS/0002

• Date of REC Opinion

  24 Jan 2019

• REC opinion

  Favourable Opinion