Noninvasive and invasive characterisation of HFpEF

• Research type

  Research Study

• Full title

  Accurate characterisation of Heart Failure with preserved Ejection Fraction (HFpEF) using advanced CMR, invasive pressure volume loop analysis and myocardial biopsies.

• IRAS ID

  166921

• Contact name

  Jessica Webb

• Contact email

  jessica.webb@kcl.ac.uk

• Sponsor organisation

  KIng's College University

• Duration of Study in the UK

  3 years, 0 months, 0 days

• Research summary

  Outline of project
  Heart failure with preserved ejection fraction (HFpEF) occurs when the heart can’t relax properly in between each heartbeat. This makes the heart muscle stiffer and more difficult to stretch. It is difficult to diagnose because ultrasound of the heart (echo) does not identify all patients. It is important to diagnose and characterise so trials can be set up in the future looking at which treatments work best.

  What is the purpose of the study?
  The purpose of this study is to see if cardiac magnetic resonance imaging (MRI) scans can help diagnose HFpEF by detecting muscle stiffness. We will compare the MRI scans with the results of invasive tests - looking at the different pressures in your heart during the heart beat (pressure volume loop studies) and biopsies of the heart.

• REC name

  London - South East Research Ethics Committee

• REC reference

  15/LO/0238

• Date of REC Opinion

  31 Mar 2015

• REC opinion

  Further Information Favourable Opinion