Non-invasive diagnosis of laryngeal closure
Research type
Research Study
Full title
Evaluation of a simple hand-held device for the assessment of wheeze and breathlessness in adolescents and young adults
IRAS ID
197564
Contact name
James Hull
Contact email
Sponsor organisation
Royal Brompton Hospital
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
The aim of this research is to evaluate the utility of a novel hand-held device, termed the airflow perturbation device (APD), as well as an already marketed device (RESMON), both using similar techniques (impulse oscillometry, IOS) to diagnose a condition in which the voice box closes during exercise to cause breathlessness and wheeze. This condition, termed exercise-induced laryngeal obstruction (EILO) is usually diagnosed using an invasive technique of continuous laryngoscopy (CLE) during exercise. Impulse oscillometry provides airflow resistance data from passive tidal respiration and is simple to use and non-invasive. Published data, to date, using the APD, in small numbers, indicates that it can provide repeatable measures and detect laryngeal closure and this pilot study will extend these early reliability studies by evaluating the performance and validity of IOS in an applied clinical context. We propose to study 30 adolescent and young adult patients referred with exertional breathlessness and to compare the data from IOS against the gold standard exercise methodologies currently employed. i.e. the direct visualization technique of CLE. An age and gender matched control group will be used as a comparator (n=10).
Secondary aims include an evaluation of the measures obtained with standard spirometric indices of airway function (including inspiratory flow) and validated questionnaires of breathlessness.REC name
South West - Central Bristol Research Ethics Committee
REC reference
16/SW/0252
Date of REC Opinion
21 Sep 2016
REC opinion
Further Information Favourable Opinion