Non-invasive determination of LV pressure-volume relations
Research type
Research Study
Full title
Non-invasive determination of left ventricular pressure-volume relations
IRAS ID
230045
Contact name
Ajay Shah
Contact email
Sponsor organisation
Kings College London
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
Heart failure is an increasingly common condition affecting at least 900000 people in the United Kingdom. It is a complex syndrome characterised by a reduced efficiency in the heart functioning as a pump. In half of patients with heart failure, the pumping action of the heart is normal and the loss in pump efficiency is primarily attributable to abnormal relaxation of the heart during each heartbeat. This condition is called ‘heart failure with preserved ejection fraction’. At present, this condition is difficult to diagnose as accurate measurements of pressure and volume of the left heart is required and this is only achievable at the time of cardiac catheterisation, which is a time consuming and invasive procedure.
In this study, we would like to validate a new technology that allows pressure and volume measurements of the left heart to be obtained non-invasively by ultrasound or magnetic resonance imaging (MRI). These new measurements will be compared against ‘gold-standard’ measurements obtained during cardiac catheterisation to determine their accuracy, precision and reliability. Adult patients, age 18-80 years with clinical indication for cardiac catheterisation will be invited to participate in this validation study at King’s College and St Thomas’ Hospitals. The research measurements will be carried out after completion of their planned procedure and both invasive and non-invasive research measurements will be acquired and compared. If these new non-invasive measurements performed well, it has the potential to improve our diagnosis and treatment of heart failure.
REC name
London - Stanmore Research Ethics Committee
REC reference
18/LO/1656
Date of REC Opinion
13 Nov 2018
REC opinion
Further Information Favourable Opinion