Non-invasive assessment of cardiovascular risk in Lupus
Research type
Research Study
Full title
A pilot study of a non-invasive tool, photoplethysmography (PPG), to assess cardiovascular risk in patients with Systemic Lupus Erythematosus.
IRAS ID
302639
Contact name
Natasha Jordan
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 4 months, 30 days
Research summary
Patients with Lupus have higher than average prevalence of cardiovascular disease, particularly female patients. Despite the evidence of increased prevalence of cardiovascular disease, there is limited understanding of how to best assess cardiovascular risk factors. Considering the range and potential severity of the symptoms, a process which can acquire valuable, reliable information is highly desirable.
The proposed pilot study is looking at whether a simple to complete, low cost, low risk physiological assessment tool can be used to assess blood flow in the hands of patients with lupus. Two non-invasive sensors will be lightly applied to of each of the patient’s thumbs. Measurements will be taken in a rested state in a seated position. The signals from the sensors be compared (right arm vs left arm), in addition to a comparison to a clinical assessment of the patient’s medical records. The information obtained will be used to design full scale study to further investigate the value of the technique.REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
22/EE/0135
Date of REC Opinion
23 May 2022
REC opinion
Favourable Opinion