Nocturnal dialysis and cardiovascular disease
Research type
Research Study
Full title
INVESTIGATING THE CARDIOVASCULAR EFFECTS OF 12 MONTHS HOME BASED NOCTURNAL HAEMODIALYSIS TREATMENT VERSUS CONVENTIONAL UNIT HAEMODIALYSIS: A NON-RANDOMISED, CONTROLLED PILOT STUDY
IRAS ID
250304
Contact name
Karen Brown
Contact email
Sponsor organisation
ABMU Health Board
Duration of Study in the UK
3 years, 7 months, 1 days
Research summary
INVESTIGATING THE CARDIOVASCULAR EFFECTS OF 12 MONTHS HOME BASED NOCTURNAL HAEMODIALYSIS VERSUS CONVENTIONAL UNIT HAEMODIALYSIS TREATMENT: A NON-RANDOMISED,SINGLE CENTRE,CONTROLLED PILOT STUDY.
To compare the impact of two different forms of dialysis [a machine that cleans the blood when patient's kidneys fail] on the function of the heart. Dialysis is normally carried out three times a week in a hospital (conventional in centre haemodialysis) but can be done at home by patients in the day or overnight when they have received training and are confident (short daily/ nocturnal haemodialysis).
Patients on dialysis have a high risk of death, half of which are due to problems with the heart and blood vessels. To assess the impact of longer night time dialysis on the function of the heart, blood tests measuring the levels of inflammation, stress and heart damage will be taken. These will be collected in patients whose kidneys have failed before and during the year after starting the dialysis type of their choice.
The kidneys are responsible for removing fluid as well as toxins from the blood, if the body becomes overloaded this can put pressure on the heart and cause heart failure and death. Three types of scans will be used to assess how well the different sorts of dialysis remove fluid and the impact on the heart; an Echocardiogram and USCOM [both jelly scans of the heart] for all groups, including the healthy volunteers. The dialysis patients will also have a CT scan [whole body x-ray scan which uses radiation to take pictures as thin slices across the body].
We hypothesize that nocturnal haemodialysis exerts a favourable effect on the function of the heart in dialysis patients by reducing the generation of inflammatory markers and avoiding damage to the heart caused by low blood pressure due to fluid removal on dialysis.
REC name
Wales REC 7
REC reference
18/WA/0317
Date of REC Opinion
26 Sep 2018
REC opinion
Favourable Opinion