nNOS and neurovascular coupling

• Research type

  Research Study

• Full title

  The role of neuronal nitric oxide synthase in the regulation of neurovascular coupling

• IRAS ID

  251206

• Contact name

  Ajay Shah

• Contact email

  ajay.shah@kcl.ac.uk

• Sponsor organisation

  King's College London

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  Neuronal nitric oxide synthase nNOS is an enzyme in the human body that produces nitric oxide, an important molecule that widens blood vessels. This study will investigate the role of nNOS in helping regulate how the body controls how much blood flows through the blood vessels to the brain. We will do this by blocking the action of nNOS using a molecule called S-methyl-L-thiocitrulline (STMC), which we have previously used in other research protocols (over 200 subjects without any adverse effects). The data generated by this study will further our understanding of how brain blood flow is regulated.

• REC name

  London - Dulwich Research Ethics Committee

• REC reference

  18/LO/2064

• Date of REC Opinion

  17 Jan 2019

• REC opinion

  Further Information Favourable Opinion